Article

Exome-wide association studies discover germline mutation patterns and identify high-risk populations in human cancers

2022-06-16

Abstract excerpt

Genome-wide association studies have discovered numerous common variants associated with human cancers. However, the contribution of exome-wide rare variants to cancers remains largely unexplored, especially for the protein-coding variants. The UK Biobank provides detailed cancer follow-up information linked to whole-exome sequencing (WES) for approximately 450,000 participants, offering an unprecedented opportuni...

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Literature Corpus work: ed439702-06a1-541f-9ca6-988ae8441090
DOI: 10.1101/2022.06.11.22275897

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