Article
The impact of rare germline variants on human somatic mutation processes
2021-11-14
Abstract excerpt
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes are known. We performed a comprehensive gene-based rare variant association study with diverse mutational processes, using human cancer genomes from over 11,000 individuals of European ancestry....
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Identifiers and source
- Literature Corpus work
- 26232614-d030-5c7e-b5c9-417088e102d0
- DOI
- 10.1101/2021.11.14.468508