Article
Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.
PloS one - 1 Jan 2011
Kovacic Melinda Butsch, Myers Jocelyn M Biagini, Wang Ning, Martin Lisa J, Lindsey Mark, Ericksen Mark B, He Hua, Patterson Tia L, Baye Tesfaye M, Torgerson Dara, Roth Lindsey A, Gupta Jayanta, Sivaprasad Umasundari, Gibson Aaron M, Tsoras Anna M, Hu Donglei, Eng Celeste, Chapela Rocío, Rodríguez-Santana José R, Rodríguez-Cintrón William, Avila Pedro C, Beckman Kenneth, Seibold Max A, Gignoux Chris, Musaad Salma M, Chen Weiguo, Burchard Esteban González, Hershey Gurjit K Khurana
Abstract excerpt
BACKGROUND: Asthma is a chronic inflammatory disease with a strong genetic predisposition. A major challenge for candidate gene association studies in asthma is the selection of biologically relevant genes. METHODOLOGY/PRINCIPAL FINDINGS: Using epithelial RNA expression arrays, HapMap allele freq...
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