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Article

The Response Regulator BfmR Is a Potential Drug Target for Acinetobacter baumannii

12 May 2016

Abstract excerpt

Identification and validation is the first phase of target-based antimicrobial development. BfmR (RstA), a response regulator in a two-component signal transduction system (TCS) in Acinetobacter baumannii, is an intriguing potential antimicrobial target. A unique characteristic of BfmR is that its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to...

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PMID: 27303741
DOI: 10.1128/msphere.00082-16

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