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Article

Francisella novicida Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production.

Frontiers in cellular and infection microbiology - 1 Jan 2020

Dean Scott N, Milton Morgan E, Cavanagh John, van Hoek Monique L

Abstract excerpt

Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella novicida, FTN_1452 that we have named BfpR (Biofilm-regulating Francisella protein Regulator,...

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PMID: 32232010
DOI: 10.3389/fcimb.2020.00082
PMCID: PMC7082314

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