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Article

Upregulation of the Adhesin Gene <i>EPA1</i> Mediated by <i>PDR1</i> in Candida glabrata Leads to Enhanced Host Colonization

3 Mar 2016

Abstract excerpt

Candida glabrata is the second most common Candida species causing disseminated infection, after C. albicans. C. glabrata is intrinsically less susceptible to the widely used azole antifungal drugs and quickly develops secondary resistance. Resistance typically relies on drug efflux with transporters regulated by the transcription factor Pdr1. Gain-of-function (GOF) mutations in PDR1 lead to a hyperactive state...

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PMID: 27303714
DOI: 10.1128/msphere.00065-15

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