Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells.

Stem cells (Dayton, Ohio) - 1 Nov 2016

Capowski Elizabeth E, Wright Lynda S, Liang Kun, Phillips M Joseph, Wallace Kyle, Petelinsek Anna, Hagstrom Anna, Pinilla Isabel, Borys Katarzyna, Lien Jessica, Min Jee Hong, Keles Sunduz, Thomson James A, Gamm David M

Abstract excerpt

Few gene targets of Visual System Homeobox 2 (VSX2) have been identified despite its broad and critical role in the maintenance of neural retina (NR) fate during early retinogenesis. We performed VSX2 ChIP-seq and ChIP-PCR assays on early stage optic vesicle-like structures (OVs) derived from human iPS cells (hiPSCs), which highlighted WNT pathway genes as direct regulatory targets of VSX2. Examination of early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzothiazoles
Share to Embryoid Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microphthalmia-Associated Transcription Factor

Share to Microphthalmos

Share to Primary Cell Culture

Share to Retinal Pigment Epithelium

Share to Wnt Signaling Pathway

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 27301076
DOI: 10.1002/stem.2414
PMCID: PMC5156591

Genes

VSX2
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells.PMID 27301076Read ↗

Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.Semantic proximity Read ↗

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.Semantic proximity Read ↗

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.Semantic proximity Read ↗

Mutation of Vsx genes in zebrafish highlights the robustness of the retinal specification networkSemantic proximity Read ↗

Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network.Semantic proximity Read ↗

Single cell profiling of CRISPR/Cas9-induced OTX2 deficient retinas reveals fate switch from restricted progenitorsSemantic proximity Read ↗

Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells that drive retinal layer structureSemantic proximity Read ↗

LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.Semantic proximity Read ↗

Efficient embryoid-based method to improve generation of optic vesicles from human induced pluripotent stem cellsSemantic proximity Read ↗

Identification of Evolutionarily Conserved VSX2 Enhancers in Retinal DevelopmentSemantic proximity Read ↗

Microphthalmia and disrupted retinal development due to a <i>LacZ</i> knock-in/knock-out allele at the <i>Vsx2</i> locusSemantic proximity Read ↗

Porcn is essential for growth and invagination of the mammalian optic cupSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.