Article

Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells that drive retinal layer structure

2025-06-23

Abstract excerpt

<h4>SUMMARY</h4> The mechanism underlying retinal spheroid layer formation was investigated using Rax::GFP-positive retinal progenitor cells from human embryonic stem cell-derived retinal organoids. Single-cell RNA sequencing revealed that well-layered spheroids transiently activated canonical WNT2B–FZD7 signaling followed by temporary expression of non-canonical WNT5A. Despite structural differences in vitro, no...

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Literature Corpus work: 44672dfc-850f-5ca6-92f6-847d5a734cd4
DOI: 10.1101/2025.06.20.660659

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