Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions.

Journal of cell science - 1 Aug 2016

Torsello Barbara, Bianchi Cristina, Meregalli Chiara, Di Stefano Vitalba, Invernizzi Lara, De Marco Sofia, Bovo Giorgio, Brivio Rinaldo, Strada Guido, Bombelli Silvia, Perego Roberto A

Abstract excerpt

Renal tubular cells are involved in the tubular interstitial fibrosis observed in diabetic nephropathy. It is debated whether epithelial-mesenchymal transition (EMT) affects tubular cells, which under high-glucose conditions overproduce transforming growth factor-β (TGF-β), a fibrogenic cytokine involved in interstitial fibrosis development. Our study investigated the involvement of non-receptor tyrosine kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Guanine Nucleotide Exchange Factors
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kidney Tubules

Share to NIH 3T3 Cells

Share to Phosphotyrosine

Share to Proteasome Inhibitors

Share to rhoA GTP-Binding Protein

Share to Stress Fibers

Source

Identifiers

PMID: 27298228
DOI: 10.1242/jcs.183640

Genes

ARHGAP35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions.PMID 27298228Read ↗

Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachmentSemantic proximity Read ↗

TGF-β1/p53 signaling in renal fibrogenesis.Semantic proximity Read ↗

The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.Semantic proximity Read ↗

Unraveling reno-protective effects of SGLT2 inhibition in human proximal tubular cellsSemantic proximity Read ↗

AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis.Semantic proximity Read ↗

A Critical Look at Growth Factors and Epithelial-to-Mesenchymal Transition in the Adult KidneySemantic proximity Read ↗

Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells.Semantic proximity Read ↗

HK-2 cell response to TGF-β highly depends on cell culture medium formulationsSemantic proximity Read ↗

Phenotypic transitions and fibrosis in diabetic nephropathy.Semantic proximity Read ↗

Activin B mediates fibrosis in diabetic kidney diseaseSemantic proximity Read ↗

C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy.Semantic proximity Read ↗

RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.