Article
Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.
Communications biology - 12 May 2022
Xia Yuxing, Prokop Stefan, Bell Brach M, Gorion Kimberly-Marie M, Croft Cara L, Nasif Lith, Xu Guilian, Riffe Cara J, Manaois Alyssa N, Strang Kevin H, Quintin Stephan S, Paterno Giavanna, Tansey Malú Gámez, Borchelt David R, Golde Todd E, Giasson Benoit I
Abstract excerpt
Pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at transgene levels below endogenous mouse tau protein levels. This mouse model develops a predictable temporal progression of tau pathology in the brain with biochemical and...
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