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Article

Functional divergence of SIR2 orthologs between trypanosomatid parasites.

Molecular and biochemical parasitology - 1 Jun 2016

Vergnes Baptiste, Gazanion Elodie, Grentzinger Thomas

Abstract excerpt

SIR2 proteins are NAD+-dependent deacetylases involved in epigenetic control of gene expression and metabolic regulation through post-translational modification of diverse target proteins. In pathogens, these enzymes are considered as attractive drug targets involved in key aspects of the infectious cycle. Leishmania infantum LiSIR2rp1 was among the first non-nuclear and essential SIR2 deacetylases described in...

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Identifiers

PMID: 27297183
DOI: 10.1016/j.molbiopara.2016.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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