Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.

Cancer research - 1 Jul 2007

Jiao Jing, Wang Shunyou, Qiao Rong, Vivanco Igor, Watson Philip A, Sawyers Charles L, Wu Hong

Abstract excerpt

PTEN mutations are among the most frequent genetic alterations found in human prostate cancers. Our previous works suggest that although precancerous lesions were found in Pten heterozygous mice, cancer progression and metastasis only happened when both alleles of Pten were deleted. To understand the molecular mechanisms underlying the role of PTEN in prostate cancer control, we generated two pairs of isogenic,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agar
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes

Share to Gene Expression Regulation, Neoplastic

Share to Karyotyping

Share to Mice, Knockout

Share to Prostatic Neoplasms

Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 17616663
DOI: 10.1158/0008-5472.CAN-06-4202

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.PMID 17616663Read ↗

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.Semantic proximity Read ↗

<i>Pten</i> Inactivation and the Emergence of Androgen-Independent Prostate CancerSemantic proximity Read ↗

The PTEN Conundrum: How to Target PTEN-Deficient Prostate CancerSemantic proximity Read ↗

Characterization of novel cell lines derived from a MYC-driven murine model of lethal metastatic adenocarcinoma of the prostate.Semantic proximity Read ↗

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.Semantic proximity Read ↗

Pten dose dictates cancer progression in the prostate.Semantic proximity Read ↗

Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-lossSemantic proximity Read ↗

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.Semantic proximity Read ↗

Modeling prostate cancer in mice: limitations and opportunities.Semantic proximity Read ↗

Mouse Models of Prostate CancerSemantic proximity Read ↗

The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancerSemantic proximity Read ↗

Context-Dependent Hormone-Refractory Progression Revealed through Characterization of a Novel Murine Prostate Cancer Cell LineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.