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Article

Common Driver Mutations in AML: Biological Impact, Clinical Considerations, and Treatment Strategies.

Cells - 21 Aug 2024

Nong Tiffany, Mehra Shefali, Taylor Justin

Abstract excerpt

Next-generation sequencing of samples from patients with acute myeloid leukemia (AML) has revealed several driver gene mutations in adult AML. However, unlike other cancers, AML is defined by relatively few mutations per patient, with a median of 4-5 depending on subtype. In this review, we will discuss the most common driver genes found in patients with AML and focus on the most clinically relevant ones that...

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Identifiers

PMID: 39195279
DOI: 10.3390/cells13161392
PMCID: PMC11352998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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