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Article

Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2007

Albertí E, Mikkelsen H B, Wang X Y, Díaz M, Larsen J O, Huizinga J D, Jiménez M

Abstract excerpt

The aim of this study was to characterize the pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats, which harbor a mutation in the c-kit gene that affects development of interstitial cells of Cajal (ICC). In Ws/Ws rats, the density of KIT-positive cells was markedly reduced. Wild-type, but not Ws/Ws, rats showed low- and high-frequency cyclic depolarization that were associated...

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Source

Identifiers

PMID: 17322067
DOI: 10.1152/ajpgi.00136.2006

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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