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Article

Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential.

American journal of physiology. Gastrointestinal and liver physiology - 15 Dec 2015

Gross Stefanie, Balderes Dina, Liu Jing, Asfaha Samuel, Gu Guoqiang, Wang Timothy C, Sussel Lori

Abstract excerpt

There are two major stem cell populations in the intestinal crypt region that express either Bmi1 or Lgr5; however, it has been shown that other populations in the crypt can regain stemness. In this study, we demonstrate that the transcription factor NK2 homeobox 2 (Nkx2.2) is expressed in enteroendocrine cells located in the villus and crypt of the intestinal epithelium and is coexpressed with the stem cell...

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Identifiers

PMID: 26492922
DOI: 10.1152/ajpgi.00244.2015
PMCID: PMC4683302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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