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Article

Cross-talk between AMPK and EGFR dependent Signaling in Non-Small Cell Lung Cancer.

Scientific reports - 9 Jun 2016

Praveen Paurush, Hülsmann Helen, Sültmann Holger, Kuner Ruprecht, Fröhlich Holger

Abstract excerpt

Lung cancers globally account for 12% of new cancer cases, 85% of these being Non Small Cell Lung Cancer (NSCLC). Therapies like erlotinib target the key player EGFR, which is mutated in about 10% of lung adenocarcinoma. However, drug insensitivity and resistance caused by second mutations in the EGFR or aberrant bypass signaling have evolved as a major challenge in controlling these tumors. Recently, AMPK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

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Source

Open in PubMed Open full text

Identifiers

PMID: 27279498
DOI: 10.1038/srep27514
PMCID: PMC4899720

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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