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Article

The Crosstalk Mechanism of EGFR and ER in EGFR-Mutant Lung Adenocarcinoma.

Cells - 6 Jan 2026

Chen Ying-Yi, Huang Wei-Ting, Su Yu-Fu, Hung Yi-Jen, Shui Hao-Ai, Shieh Yi-Shing, Huang Tsai-Wang

Abstract excerpt

Breast cancer and lung adenocarcinoma share common features, including female predominance and the expression of estrogen receptor (ER) and epidermal growth factor receptor (EGFR) during carcinogenesis. Patients with breast cancer have a significantly higher risk of developing second primary lung cancer than those without breast cancer. ER beta expression is associated with resistance to EGFR tyrosine kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41597172
DOI: 10.3390/cells15020098
PMCID: PMC12838910

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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