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Article

Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC.

Oncogene - 1 Feb 2021

Cheng Fang-Ju, Chen Chia-Hung, Tsai Wen-Chen, Wang Bo-Wei, Yu Meng-Chieh, Hsia Te-Chun, Wei Ya-Ling, Hsiao Yu-Chun, Hu Dai-Wei, Ho Chien-Yi, Li Tzong-Shiun, Wu Chun-Yi, Chou Wen-Yu, Yu Yung-Luen, Tang Chih-Hsin, Chen Chih-Yi, Chen Chuan-Mu, Hsu Jennifer L, Chen Hsiao-Fan, Chen Yeh, Tu Chih-Yen, Hung Mien-Chie, Huang Wei-Chien

Abstract excerpt

Smoker patients with non-small cell lung cancer (NSCLC) have poorer prognosis and survival than those without smoking history. However, the mechanisms underlying the low response rate of those patients to EGFR tyrosine kinase inhibitors (TKIs) are not well understood. Here we report that exposure to cigarette smoke extract enhances glycolysis and attenuates AMP-activated protein kinase (AMPK)-dependent inhibition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33335306
DOI: 10.1038/s41388-020-01597-1
PMCID: PMC7878190

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