Article
The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells.
BMC genomics - 9 Jun 2016
Hansen Stine Ninel, Ehlers Natasja Spring, Zhu Shida, Thomsen Mathilde Borg Houlberg, Nielsen Rikke Linnemann, Liu Dongbing, Wang Guangbiao, Hou Yong, Zhang Xiuqing, Xu Xun, Bolund Lars, Yang Huanming, Wang Jun, Moreira Jose, Ditzel Henrik J, Brünner Nils, Schrohl Anne-Sofie, Stenvang Jan, Gupta Ramneek
Abstract excerpt
BACKGROUND: Resistance to taxane-based therapy in breast cancer patients is a major clinical problem that may be addressed through insight of the genomic alterations leading to taxane resistance in breast cancer cells. In the current study we used whole exome sequencing to discover somatic genomic alterations, evolving across evolutionary stages during the acquisition of docetaxel resistance in breast cancer cell...
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