Article

Tracing the evolutionary trajectory of CDK4/6 inhibitor resistance in oestrogen receptor positive breast cancer

2025-09-04

Abstract excerpt

<title>Abstract</title> <p>Understanding tumour evolution is key to overcoming resistance to CDK4/6 inhibitors (CDK4/6i) in oestrogen receptor positive breast cancer. While genetic changes contribute, many patients lack identifiable mutations, suggestive of non-genetic epigenetic reprogramming and transcriptional plasticity. Here, we integrate expressed barcode lineage tracing, single-cell and bulk profiling, tog...

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Literature Corpus work: a7acfa94-1bb5-5f94-bb07-3f7c50e32c17
DOI: 10.21203/rs.3.rs-7488427/v1

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