Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance.

doi:10.1242/dmm.032292

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Article

Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance.

Disease models & mechanisms - 18 May 2018

Ruiz de Garibay Gorka, Mateo Francesca, Stradella Agostina, Valdés-Mas Rafael, Palomero Luis, Serra-Musach Jordi, Puente Diana A, Díaz-Navarro Ander, Vargas-Parra Gardenia, Tornero Eva, Morilla Idoia, Farré Lourdes, Martinez-Iniesta María, Herranz Carmen, McCormack Emmet, Vidal August, Petit Anna, Soler Teresa, Lázaro Conxi, Puente Xose S, Villanueva Alberto, Pujana Miguel Angel

Abstract excerpt

Understanding the mechanisms of cancer therapeutic resistance is fundamental to improving cancer care. There is clear benefit from chemotherapy in different breast cancer settings; however, knowledge of the mutations and genes that mediate resistance is incomplete. In this study, by modeling chemoresistance in patient-derived xenografts (PDXs), we show that adaptation to therapy is genetically complex and...

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Identifiers

PMID: 29666142
DOI: 10.1242/dmm.032292
PMCID: PMC5992609

Genes

TCF4
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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