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DNMT3A triggers tumorigenesis of non-small cell lung cancer through regulation of SLIT2 methylation and SLIT2-mediated macrophage M1/M2 polarization

28 May 2025

Abstract excerpt

BACKGROUND: Increased DNA methylation is prevalent in human cancers and is one of the important characteristics of tumors. This research aims to investigate the molecular mechanisms that involve DNMT3A and DNA methylation modification of SLIT2 in non-small cell lung cancer (NSCLC). METHODS: Gene expression was examined using Western blot assay, immunohistochemistry and RT-qPCR. Cell viability and motility were...

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PMID: 40447165
DOI: 10.1016/j.mcp.2025.102033

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