Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

5 Jun 2020

Abstract excerpt

Tumor-associated macrophages (TAMs) influence lung tumor development by inducing immunosuppression. Transcriptome analysis of TAMs isolated from human lung tumor tissues revealed an up-regulation of the Wnt/β-catenin pathway. These findings were reproduced in a newly developed in vitro "trained" TAM model. Pharmacological and macrophage-specific genetic ablation of β-catenin reprogrammed M2-like TAMs to M1-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cancer-related gene regulation
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32548260
DOI: 10.1126/sciadv.aaz6105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancerPMID 32548260Read ↗

Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung CarcinomaSemantic proximity Read ↗

Macrophages, Inflammation, and Lung Cancer.Semantic proximity Read ↗

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in MiceSemantic proximity Read ↗

Regulatory Networks Shaping Human Tumor-Associated Macrophages In Vivo Identify MAFB as a Key Transcriptional DriverSemantic proximity Read ↗

Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages.Semantic proximity Read ↗

Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkersSemantic proximity Read ↗

Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to TalkSemantic proximity Read ↗

Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression.Semantic proximity Read ↗

Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine ExpressionSemantic proximity Read ↗

KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.Semantic proximity Read ↗

Activin-A Impedes the Establishment of CD4+ T Cell Exhaustion and Enhances Anti-Tumor Immunity in the LungSemantic proximity Read ↗

Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.