Article
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers.
Scientific reports - 7 Jun 2016
Qiu Zhixin, Zou Keke, Zhuang Liping, Qin Jianjie, Li Hong, Li Chao, Zhang Zhengtao, Chen Xiaotao, Cen Jin, Meng Zhiqiang, Zhang Haibin, Li Yixue, Hui Lijian
Abstract excerpt
Hepatocellular carcinoma (HCC) cell lines are useful in vitro models for the study of primary HCCs. Because cell lines acquire additional mutations in culture, it is important to understand to what extent HCC cell lines retain the genetic landscapes of primary HCCs. Most HCC cell lines were established during the last century, precluding comparison between cell lines and primary cancers. In this study, 9 Chinese...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.