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Article

Multi-omics Analysis of Primary Cell Culture Models Reveals Genetic and Epigenetic Basis of Intratumoral Phenotypic Diversity.

Genomics, proteomics & bioinformatics - 1 Dec 2019

Liu Sixue, Yang Zuyu, Li Guanghao, Li Chunyan, Luo Yanting, Gong Qiang, Wu Xin, Li Tao, Zhang Zhiqian, Xing Baocai, Xu Xiaolan, Lu Xuemei

Abstract excerpt

Uncovering the functionally essential variations related to tumorigenesis and tumor progression from cancer genomics data is still challenging due to the genetic diversity among patients, and extensive inter- and intra-tumoral heterogeneity at different levels of gene expression regulation, including but not limited to the genomic, epigenomic, and transcriptional levels. To minimize the impact of germline genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32205176
DOI: 10.1016/j.gpb.2018.07.008
PMCID: PMC7212478

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