Article
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.
Nature communications - 7 Jun 2016
Nucifora Frederick C, Nucifora Leslie G, Ng Chee-Hoe, Arbez Nicolas, Guo Yajuan, Roby Elaine, Shani Vered, Engelender Simone, Wei Dong, Wang Xiao-Fang, Li Tianxia, Moore Darren J, Pletnikova Olga, Troncoso Juan C, Sawa Akira, Dawson Ted M, Smith Wanli, Lim Kah-Leong, Ross Christopher A
Abstract excerpt
A common genetic form of Parkinson's disease (PD) is caused by mutations in LRRK2. We identify WSB1 as a LRRK2 interacting protein. WSB1 ubiquitinates LRRK2 through K27 and K29 linkage chains, leading to LRRK2 aggregation and neuronal protection in primary neurons and a Drosophila model of G2019S LRRK2. Knocking down endogenous WSB1 exacerbates mutant LRRK2 neuronal toxicity in neurons and the Drosophila model,...
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