Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

doi:10.1128/MCB.00914-13

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Article

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

Molecular and cellular biology - 1 Jun 2014

Piccoli Giovanni, Onofri Franco, Cirnaru Maria Daniela, Kaiser Christoph J O, Jagtap Pravinkumar, Kastenmüller Andreas, Pischedda Francesca, Marte Antonella, von Zweydorf Felix, Vogt Andreas, Giesert Florian, Pan Lifeng, Antonucci Flavia, Kiel Christina, Zhang Mingjie, Weinkauf Sevil, Sattler Michael, Sala Carlo, Matteoli Michela, Ueffing Marius, Gloeckner Christian Johannes

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains, including predicted C-terminal WD40 repeats. In this study, we analyzed functional and molecular features conferred by the WD40 domain. Electron microscopic analysis of the purified LRRK2 C-terminal domain revealed...

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Identifiers

PMID: 24687852
DOI: 10.1128/MCB.00914-13
PMCID: PMC4054300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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