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Article

Genetic Variations in FSH Action Affect Sex Hormone Levels and Breast Tissue Size in Infant Girls: A Pilot Study.

The Journal of clinical endocrinology and metabolism - 1 Aug 2016

Henriksen Louise Scheutz, Hagen Casper P, Assens Maria, Busch Alexander S, Skakkebæk Niels E, Almstrup Kristian, Main Katharina M

Abstract excerpt

CONTEXT: Single nucleotide polymorphisms altering FSH action (FSHB -211G>T, FSHR -29G>A, and FSHR 2039A>G) are associated with peripubertal and adult levels of reproductive hormones and age at pubertal onset in girls. OBJECTIVE: To investigate whether genetic polymorphisms altering FSH action affect serum levels of female reproductive hormones and breast development as early as during minipuberty. DESIGN:...

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Source

Identifiers

PMID: 27270476
DOI: 10.1210/jc.2016-1672

Genes

FSHR
FSHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic Variations in FSH Action Affect Sex Hormone Levels and Breast Tissue Size in Infant Girls: A Pilot Study.PMID 27270476Read ↗

Genetic variations altering FSH action affect circulating hormone levels as well as follicle growth in healthy peripubertal girls.Semantic proximity Read ↗

FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study.Semantic proximity Read ↗

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Pharmacogenetics of FSH Action in the FemaleSemantic proximity Read ↗

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FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2020 men from the general Danish population.Semantic proximity Read ↗

Effects of the FSH-β-subunit promoter polymorphism -211G->T on the hypothalamic-pituitary-ovarian axis in normally cycling women indicate a gender-specific regulation of gonadotropin secretion.Semantic proximity Read ↗

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