Article
FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study.
Fertility and sterility - 1 Oct 2013
Hagen Casper P, Aksglaede Lise, Sørensen Kaspar, Mouritsen Annette, Mieritz Mikkel G, Main Katharina M, Petersen Jørgen Holm, Almstrup Kristian, Rajpert-De Meyts Ewa, Anderson Richard A, Juul Anders
Abstract excerpt
OBJECTIVE: To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antimüllerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of...
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