Article
Cutaneous pH landscape as a facilitator of melanoma initiation and progression.
Acta physiologica (Oxford, England) - 1 Jan 2019
Koch A, Schwab A
Abstract excerpt
Melanoma incidence is on the rise and currently causes the majority of skin cancer-related deaths. Yet, therapies for metastatic melanoma are still insufficient so that new concepts are essential. Malignant transformation of melanocytes and melanoma progression are intimately linked to the cutaneous pH landscape and its dysregulation in tumour lesions. The pH landscape of normal skin is characterized by a large...
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