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Article

Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes.

PLoS genetics - 15 Apr 2010

Carney Thomas J, Feitosa Natália Martins, Sonntag Carmen, Slanchev Krasimir, Kluger Johannes, Kiyozumi Daiji, Gebauer Jan M, Coffin Talbot Jared, Kimmel Charles B, Sekiguchi Kiyotoshi, Wagener Raimund, Schwarz Heinz, Ingham Phillip W, Hammerschmidt Matthias

Abstract excerpt

Using forward genetics, we have identified the genes mutated in two classes of zebrafish fin mutants. The mutants of the first class are characterized by defects in embryonic fin morphogenesis, which are due to mutations in a Laminin subunit or an Integrin alpha receptor, respectively. The mutants of the second class display characteristic blistering underneath the basement membrane of the fin epidermis. Three of...

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Share to Amino Acid Sequence
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Gene Expression Regulation, Developmental

Share to Proprotein Convertases

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20419147
DOI: 10.1371/journal.pgen.1000907
PMCID: PMC2855323

Genes

FRAS1
FREM1
FREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes.PMID 20419147Read ↗

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