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A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons

13 Feb 2019

Abstract excerpt

The pathophysiology of most neurodegenerative diseases includes aberrant accumulation of protein aggregates. Recent evidence highlights the role of protein degradation pathways in neurodegeneration. Concurrently, genetic tools have been generated to enable zebrafish, Danio rerio, to be used as an animal model to study neurodegenerative processes. In addition to optical clarity and fast ex utero development, the...

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PMID: 30755067
DOI: 10.1080/15548627.2019.1580511

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