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Article

Small molecules that target protein misfolding.

Journal of medicinal chemistry - 27 Dec 2012

Gavrin Lori Krim, Denny Rajiah Aldrin, Saiah Eddine

Abstract excerpt

Protein misfolding is a process in which proteins are unable to attain or maintain their biologically active conformation. Factors contributing to protein misfolding include missense mutations and intracellular factors such as pH changes, oxidative stress, or metal ions. Protein misfolding is linked to a large number of diseases such as cystic fibrosis, Alzheimer's disease, Parkinson's disease, amyotrophic...

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Identifiers

PMID: 23075044
DOI: 10.1021/jm301182j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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