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Article

Hemophagocytic Lymphohistiocytosis: When the Immune System Runs Amok

25 Aug 2009

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an exaggerated but ineffective immune response leads to severe hyperinflammation. Key players in HLH are activated lymphocytes and histiocytes which infiltrate all organs and secrete large amounts of cytokines. Cardinal symptoms are prolonged fever, hepatosplenomegaly, cytopenias, and hemophagocytosis. Biochemical markers include...

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PMID: 19707989
DOI: 10.1055/s-0029-1237386

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