Article
G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK.
Cellular signalling - 1 Sept 2016
Yang Hua, Liu Haipeng, Chen Hao, Mo Haiping, Chen Jianxia, Huang Xiaocheng, Zheng Ruijuan, Liu Zhonghua, Feng Yonghong, Liu Feng, Ge Baoxue
Abstract excerpt
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, invades and replicates within susceptible hosts by disturbing host antimicrobial mechanisms. Although G protein-coupled receptors (GPCRs) are involved in most physiological and pathological activities of mammalian cells, the roles of GPCRs in Mtb invasion into host cell remain elusive. Here, we report that GPR160 expression is elevated at both...
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