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Article

PE_PGRS30 is required for the full virulence of Mycobacterium tuberculosis

3 Nov 2011

Abstract excerpt

The role and function of PE_PGRS proteins of Mycobacterium tuberculosis (Mtb) remains elusive. In this study for the first time, Mtb isogenic mutants missing selected PE_PGRSs were used to investigate their role in the pathogenesis of tuberculosis (TB). We demonstrate that the MtbΔPE_PGRS30 mutant was impaired in its ability to colonize lung tissue and to cause tissue damage, specifically during the chronic steps...

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PMID: 22050772
DOI: 10.1111/j.1462-5822.2011.01721.x

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