Article
Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells.
Infection and immunity - 1 Dec 2001
Brennan M J, Delogu G, Chen Y, Bardarov S, Kriakov J, Alavi M, Jacobs W R
Abstract excerpt
The elucidation of the genomic sequence of Mycobacterium tuberculosis revealed the presence of a novel multigene family designated PE/PE_PGRS that encodes numerous, highly related proteins of unknown function. In this study, we demonstrate that a transposon insertion in a PE_PGRS gene (1818(PE_PGRS)) found in Mycobacterium bovis BCG Pasteur, which is the BCG homologue of the M. tuberculosis H37Rv gene Rv1818c,...
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