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Impact of Protein Domains on PE_PGRS30 Polar Localization in Mycobacteria

12 Nov 2014

Abstract excerpt

PE_PGRS proteins are unique to the Mycobacterium tuberculosis complex and a number of other pathogenic mycobacteria. PE_PGRS30, which is required for the full virulence of M. tuberculosis (Mtb), has three main domains, i.e. an N-terminal PE domain, repetitive PGRS domain and the unique C-terminal domain. To investigate the role of these domains, we expressed a GFP-tagged PE_PGRS30 protein and a series of its...

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PMID: 25390359
DOI: 10.1371/journal.pone.0112482

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