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Article

Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8.

Biotechnology and bioengineering - 1 Dec 2016

Khabou Hanen, Desrosiers Mélissa, Winckler Céline, Fouquet Stéphane, Auregan Gwenaëlle, Bemelmans Alexis-Pierre, Sahel José-Alain, Dalkara Deniz

Abstract excerpt

Recently, we described a modified AAV2 vector-AAV2-7m8-having a capsid-displayed peptide insertion of 10 amino acids with enhanced retinal transduction properties. The insertion of the peptide referred to as 7m8 is responsible for high-level gene delivery into deep layers of the retina when virus is delivered into the eye's vitreous. Here, we further characterize AAV2-7m8 mediated gene delivery to neural tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27259396
DOI: 10.1002/bit.26031

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