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Cell-penetrating peptides enhance the transduction of adeno-associated virus serotype 9 in the central nervous system

27 Feb 2021

Abstract excerpt

Recombinant adeno-associated viruses (rAAVs) have been widely used in the gene therapy field for decades. However, because of the challenge of effectively delivering rAAV vectors through the blood-brain barrier (BBB), their applications for treatment of central nervous system (CNS) diseases are quite limited. In this study, we found that several cell-penetrating peptides (CPPs) can significantly enhance the in...

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PMID: 33768127
DOI: 10.1016/j.omtm.2021.02.019

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