Article
Five endometrial cancer risk loci identified through genome-wide association analysis.
Nature genetics - 1 Jun 2016
Cheng Timothy Ht, Thompson Deborah J, O'Mara Tracy A, Painter Jodie N, Glubb Dylan M, Flach Susanne, Lewis Annabelle, French Juliet D, Freeman-Mills Luke, Church David, Gorman Maggie, Martin Lynn, Hodgson Shirley, Webb Penelope M, Attia John, Holliday Elizabeth G, McEvoy Mark, Scott Rodney J, Henders Anjali K, Martin Nicholas G, Montgomery Grant W, Nyholt Dale R, Ahmed Shahana, Healey Catherine S, Shah Mitul, Dennis Joe, Fasching Peter A, Beckmann Matthias W, Hein Alexander, Ekici Arif B, Hall Per, Czene Kamila, Darabi Hatef, Li Jingmei, Dörk Thilo, Dürst Matthias, Hillemanns Peter, Runnebaum Ingo, Amant Frederic, Schrauwen Stefanie, Zhao Hui, Lambrechts Diether, Depreeuw Jeroen, Dowdy Sean C, Goode Ellen L, Fridley Brooke L, Winham Stacey J, Njølstad Tormund S, Salvesen Helga B, Trovik Jone, Werner Henrica Mj, Ashton Katie, Otton Geoffrey, Proietto Tony, Liu Tao, Mints Miriam, Tham Emma, Consortium Chibcha, Jun Li Mulin, Yip Shun H, Wang Junwen, Bolla Manjeet K, Michailidou Kyriaki, Wang Qin, Tyrer Jonathan P, Dunlop Malcolm, Houlston Richard, Palles Claire, Hopper John L, Peto Julian, Swerdlow Anthony J, Burwinkel Barbara, Brenner Hermann, Meindl Alfons, Brauch Hiltrud, Lindblom Annika, Chang-Claude Jenny, Couch Fergus J, Giles Graham G, Kristensen Vessela N, Cox Angela, Cunningham Julie M, Pharoah Paul D P, Dunning Alison M, Edwards Stacey L, Easton Douglas F, Tomlinson Ian, Spurdle Amanda B
Abstract excerpt
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (, in LOC643623 and...
