Article
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2021
Gailey Casey D, Wang Eric J, Jin Li, Ahmadi Sean, Brautigan David L, Li Xudong, Xu Wenhao, Scott Michael M, Fu Zheng
Abstract excerpt
BACKGROUND: Kinesin family member 3A (KIF3A) is a molecular motor protein in the heterotrimeric kinesin-2 complex that drives anterograde intraflagellar transport. This process plays a pivotal role in both biogenesis and maintenance of the primary cilium that supports tissue development. Ciliogenesis associated kinase 1 (CILK1) phosphorylates human KIF3A at Thr672. CILK1 loss of function causes ciliopathies that...
Topics
- Animals
- Cilia
- Ciliopathies
- Disease Models, Animal
- Female
- Gene Knock-In Techniques
- Kinesins
- Loss of Function Mutation
- Male
- Mice, Transgenic