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Article

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.

Nature cell biology - 1 Jan 2008

Corbit Kevin C, Shyer Amy E, Dowdle William E, Gaulden Julie, Singla Veena, Chen Miao-Hsueh, Chuang Pao-Tien, Reiter Jeremy F

Abstract excerpt

Primary cilia are microtubule-based organelles involved in signal transduction and project from the surface of most vertebrate cells. Proteins that can localize to the cilium, for example, Inversin and Bardet-Biedl syndrome (BBS) proteins, are implicated in both beta-catenin-dependent and -independent Wnt signalling. Given that Inversin and BBS proteins are found both at the cilium and elsewhere in the cell, the...

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PMID: 18084282
DOI: 10.1038/ncb1670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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