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Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice

8 Jun 2007

Abstract excerpt

The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related A beta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats. Three amino acid substitutions distinguish mouse and human A beta that might contribute to their differing properties in vivo. To examine the amyloidogenic potential of mouse A beta, we studied several...

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PMID: 17556372
DOI: 10.1074/jbc.m611050200

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