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Article

Heterogeneity of EGFR Aberrations and Correlation with Histological Structures: Analyses of Therapy-Naive Isogenic Lung Cancer Lesions with EGFR Mutation.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2016

Suda Kenichi, Murakami Isao, Yu Hui, Ellison Kim, Shimoji Masaki, Genova Carlo, Rivard Christopher J, Mitsudomi Tetsuya, Hirsch Fred R

Abstract excerpt

INTRODUCTION: EGFR gene somatic mutation is reportedly homogeneous. However, there are few data regarding the heterogeneity of expression of mutant EGFR protein and EGFR gene copy number, especially in extrathoracic lesions. These types of data may enhance our understanding of the biology of EGFR-mutated lung cancer and our understanding of the heterogeneous response patterns to EGFR TKIs. METHODS: An 81-year-old...

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Identifiers

PMID: 27257133
DOI: 10.1016/j.jtho.2016.05.017
PMCID: PMC5327856

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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