Article
Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2000
Egeli Unal, Ak Secil, Cecener Gulsah, Tunca Berrin, Tezcan Gulcin, Sevinc Elif Demirdogen, Kaya Ekrem, Dundar Halit Ziya, Sarkut Pinar, Ozen Yilmaz, Balcin Ozkan, Evrensel Turkkan, Yerci Omer, Ugras Nesrin
Abstract excerpt
OBJECTIVE: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the KRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). However, limited data exist on the clinical effect of these alterations. The aim of the current study was to clarify the frequency of relevant alterations of...
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