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Article

Association of KRAS variants with survival and therapeutic outcomes in biliary tract cancers.

ESMO open - 1 Jun 2025

Iida K, Matsui Y, Urabe Y, Muramatsu T, Matsuzaki J, Saito Y

Abstract excerpt

BACKGROUND: Biliary tract cancer (BTC) remains a highly aggressive malignancy with limited treatment options and poor prognosis. To explore the association between KRAS variants and survival/therapeutic outcomes of patients with BTC, we analyzed genetic and clinical data obtained from BTC patients who underwent comprehensive genomic profiling (CGP) testing in Japan. PATIENTS AND METHODS: A total of 7773 patients...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Proteins p21(ras)
Male
Female
Biliary Tract Neoplasms
Aged
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Prognosis

Aged, 80 and over

Treatment Outcome

Japan

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40499463
DOI: 10.1016/j.esmoop.2025.105306
PMCID: PMC12182791

Genes

KRAS
BTC
CAT

Variants

Provenance

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