Article
Prognostic Implications of Codon-Specific KRAS Mutations in Localized and Advanced Stages of Pancreatic Cancer.
JCO precision oncology - 1 Feb 2026
Raji Sara, Zaribafzadeh Hamed, Jones Tyler, Kanu Elishama, Tong Kunling, Fletcher Ashley, Howell T Clark, McCall Shannon J, Marks Jeffrey R, Rogers Bruce, Niedzwiecki Donna, Allen Peter J, Nussbaum Daniel P, Kabiri Zahra
Abstract excerpt
PURPOSE: Although KRAS mutations represent the primary oncogenic driver in pancreatic ductal adenocarcinoma (PDAC), the association between codon-specific alterations and patient outcomes remains poorly elucidated, largely because of a lack of data sets coupling genomic profiling with rich clinical annotations across disease stages. MATERIALS AND METHODS: We used American Association for Cancer Research's GENIE...
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