A let-7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population.

doi:10.1007/s00432-016-2254-9

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Article

A let-7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population.

Journal of cancer research and clinical oncology - 1 Dec 2016

Kazmi Hasan Raza, Chandra Abhijit, Kumar Saket, Satyam Leena Khare, Gupta Annapurna, Nigam Jaya, Srivastava Meenu, Mittal Balraj

Abstract excerpt

PURPOSE: Gallbladder cancer is a lethal malignancy of hepato-biliary system with high incidence in North India, especially along gangetic plain. The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region (rs61764370, T/G) of KRAS leads to its higher expression. This polymorphism is known to be associated with increased risk and prognosis of various cancers but...

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PMID: 27620744
DOI: 10.1007/s00432-016-2254-9

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KRAS

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A let-7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population.PMID 27620744Read ↗

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