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Article

Flt1/VEGFR1 heterozygosity causes transient embryonic edema.

Scientific reports - 2 Jun 2016

Otowa Yasunori, Moriwaki Kazumasa, Sano Keigo, Shirakabe Masanori, Yonemura Shigenobu, Shibuya Masabumi, Rossant Janet, Suda Toshio, Kakeji Yoshihiro, Hirashima Masanori

Abstract excerpt

Vascular endothelial growth factor-A is a major player in vascular development and a potent vascular permeability factor under physiological and pathological conditions by binding to a decoy receptor Flt1 and its primary receptor Flk1. In this study, we show that Flt1 heterozygous (Flt1(+/-)) mouse embryos grow up to adult without life-threatening abnormalities but exhibit a transient embryonic edema around the...

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Source

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Identifiers

PMID: 27251772
DOI: 10.1038/srep27186
PMCID: PMC4890026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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